March 05, 2018
Safety Analysis of Leishmania Vaccine Used in a Randomized Canine Vaccine/Immunotherapy Trial
In Leishmania infantum–endemic countries, controlling infection within dogs, the domestic reservoir, is critical to public health. There is a need for safe vaccines that prevent canine progression with disease and transmission to others. Protective vaccination against Leishmania requires mounting a strong, inflammatory, Type 1 response. Three commercially available canine vaccines on the global veterinary market use saponin or inflammatory antigen components (Letifend) as a strong pro-inflammatory adjuvant. There is very little information detailing safety of saponin as an adjuvant in field trials. Safety analyses for the use of vaccine as an immunotherapeutic in asymptomatically infected animals are completely lacking. Leishmania infantum, the causative agent of canine leishmaniasis, is enzootic within U.S. hunting hounds. We assessed the safety of LeishTec® after use in dogs from two different clinical states: 1) without clinical signs and tested negative on polymerase chain reaction and serology or 2) without clinical signs and positive for at least one Leishmania diagnostic test. Vaccine safety was assessed after all three vaccinations to quantify the number and severity of adverse events. Vaccinated animals had an adverse event rate of 3.09%, whereas placebo animals had 0.68%. Receiving vaccine was correlated with the occurrence of mild, site-specific, reactions. Occurrence of severe adverse events was not associated with having received vaccine. Infected, asymptomatic animals did not have a higher rate of adverse events. Use of vaccination is, therefore, likely to be safe in infected, asymptomatic animals.
Read the full article in The American of Tropical Medicine and Hygiene.
More from CNAS
-
The Enduring Relevance of Reagan’s Westminster Speech
Commentary
Editor’s Note: This is the third in a series of three essays, commissioned by the Ronald Reagan Presidential Foundation and Institute, examining the legacy of Reagan’s Westmin...
By Richard Fontaine
-
Friday Roundtable
Podcast
On the Roundtable episode of the Defense & Aerospace Podcast, Robert F. Hale joins Todd Harrison, the director of defense budget analysis and the Aerospace Security Project at...
By Robert F. Hale
-
National Security Is Made of People
Commentary
For several years, members of Congress and senior defense officials have worried, dramatically and out loud, about the state of military readiness, devoting bipartisan harangu...
By Loren DeJonge Schulman
-
Small Satellites in the Emerging Space Environment
Reports
Steven Kosiak assesses the advantages and risks of widespread networks of smaller satellites versus consolidated networks of larger satellites....
By Steven Kosiak
